It has been suggested that hyperlipidemia contributes to vasculogenic impotence by atherosclerosis-induced intraluminal occlusion, impairment of endothelium-dependent relaxation of cavemosal smooth muscle, or degeneration of the smooth muscle.
To investigate the incidence of hyperlipidemia in the population with vasculogenic impotence, 580 patients with this disorder and 95 normally potent men aged 40 to 69 years were studied.
the serum concentrations of total cholesterol (TCh), triglyceride (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), lipoprotein (Lp), a apoprotein (Apo) A1, ApoB, and phospholipid (PL) were measured.
Also, we determined whether any of the relations reported to be possible risk factors of atherosclerosis namely LDL/HDL >3.3, TCh/HDL >4.7, ApoA1/ApoB >1.3, high TG - low HDL, high TG - high ApoA1, high TG - high ApoB, or high TCh -high TG, were
present.
The incidence of abnormally high individual lipid fractions and abnormal ratios were then compared in the vasculogenicaliy impotent and potent men by statistical analysis using ANOVA and chi-square tests.
Significant differences in the incidence of abnormally high serum lipid concentrations were found only for TCh (p = 0.008) and Lpa (p = 0.019).
There was no significant difference between the two groups in any of the ratios. Hypercholesterolemia seems to be the greatest risk factor among the lipid fractions in the pathogenesis of vasculogenic impotence.
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